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PhD thesis presentation

Transcript: CSS Draining area 460ha (19,500 inhab.) Side weir CSO structure Mur River transboundary river avg flow 117m/s Full equipped monitoring station 11 Evaluate the performance and support for maintenance of CSSs Large Small S1 (2) Design and analysis of new and existing sewer systems Duration approach Objective function evaluation Low effectiveness closely related to the characteristics of the structure HOBO UA-002-64 - 63% 300 min OUTLINE - Mediterranean stream (15km) - avg flow 0.14 m/s (large variation) After rain.. 5 Conclusions CSO End Duration approach · 27 CSS Sant Feliu (Costa Brava) CSO9 - EP: 40% Weir 126% 5 so, what is the problem? - Policy and legislation development 36 6,000-17,000€ Sensitivity analysis Double T-sensor Duration 30 Sewer modeling Overflow approach Tot. Duration Potential applications return to dw cond. 25min 100 Rain to runoff Overland flow (runoff) Flow transport in the sewer (surface flooding) 2.2mm 33min 1% CSO Volume CSO 4 NSGA-II algorithm 5 rain episodes (S1,S2,M1,M2,L1) 3 Materials & Locations 7 EVALUATION PERFORMANCE of CSSs Calibration against flow or level measurements from the main sewer trunk PhD Programme on Experimental Sciences and Sustainability Case Study and Reference Model - Flow and quality measurements since 2002 CSO 3 Evaluating compliance with guidelines 1% 500-1,000€ disparity in the results 3 hypothetical regulation Large 91 Inflow channel by... 2015? (2021-2027) - Rain measurements Adapted from Devesa (2006) Support for CSS maintenance Similar results for both approaches Minimal investment 4 Main contributions 17 Motivations (3 min resolution) sensor clogging (higher maintenance) (1) CSO 6 ·High cost ·Technical knowledge requ. management strategies Rsqr.>0.7 37 86 Wide range of types of sewer models 15 - But CSOs? Now, calibration results CSO Occurrence For low SNRs further research Sensor in contact with the water in dry conditions CSO Duration (overflow approach) breaking point! The Urban Wastewater System 54 Overflow app. -> better CSO volume/peak Using CSO duration to calibrate a sewer model better CSO durations better than Reference Model Simultaneous monitoring Towards better management of combined sewer systems – a methodology based on low-cost monitoring - Other devices CSO Volume 29 0.31 4 Nash-Sutcliff coeff. Sum of Squared Errors Mean Absolute Errors Peak/Volume Absolute Errors Peak/Volume Weighted Errors (CSO Control Strategy, 1989) Data collection 5 mm Medium M1 Data retrieval manually Volume Graz West Catchment thorough implementation in 36 100% detections 32 100% (EPA, 2004) 29 Overflow approach Conductivity sensor Case study and installation setup 18 1% La Garriga CSS David Vantage Vue Tipping bucket rain sensor 0.2mm resolution (SUBMITTED) Support for CSS maintenance CSO Structure ·Moderate cost ·Low autonomy ·High maintenance CSO structure CALIBRATION 81 Key model parameters (SWMM5) Observed limitations The proposed methodology - max. deviation (predefined) CSO 12 CSO Start looking for problematic structures CSO duration Vs. Rain volume Visual Inspection Flow sensor CSO Volume Explanatory variables 25CSOs / year CSO14 136% CSO11 - EP: 54% Temperature sensors Aid the decision making Detection effectiveness compromised with low SNR - Waterproof casing - 240€ u. Characterizing performance of CSO structures Goodness of model calibration/validation - 20,000€ (Gruber et al., 2005) Legal framework 1 Introduction (PUBLISHED) CSSs in numbers Support for CSS maintenance (limited resources) La Garriga UWWS - CALIBRATION IS A MUST - Water level sensor - CSO occurrence - CSO duration Automatic calibration Response variables 11 (J48 algorithm) temperature Small 22h La Garriga CSS 13 CSO structures Total investment 900€ 2.2mm Stainless steel solid bar Battery+data logger Overflow definition depending on the rain, all 4 parameters important Temperature measurements for CSO detection Contribution 3 Both calibration appr. better performance than Reference model Null Response 29h High robustness (UNEP, 2002) 8 13 Calibration results so we have this method that works... Flow measurements 1 T sensor CSO 11 Besòs River Basin Graz West catchment measurements & key model parameters - Not Clear Response SUMMARY RESULTS PhD Thesis Expected Potential ·High cost ·Technical knowledge requ. ·Sometimes difficult to implement 26 2 1948 - FWPCA 1972 - CWA Sewer modeling Probability Personal thanks to... 27 Characterizing performance of CSO structures 4 Water quality sensor ENDERUS project (CTM-2009-13018) FPI PhD grant (BES-2010-039247) FP7 grant (PCIG9-GA-2011-293535) ICRA consolidated research group (2014 SGR 291) 3 days Useful to assess the behavior of CSO and CSSs MAIN PROCESSES 1 CSO structure equipped with flowmeter (for verification) Principle temperature differences between the sewer gas phase and the CSO ·Easy to implement Avg. order 34 Contribution 2 Overflow discharge Q measurements 1991 Urban Wastewater Treatment Directive Understand the behaviour of CSO

PhD Thesis

Transcript: Introduction PAR Ethnography Post-analysis data Analysing the data Literature Review Critique of Humean causality: much work in PA and H attempts to explain action (level of activity) by analysing variables (measurable independent variable). This can only lead to knowledge of behaviour through a closed account of linear and simplified causality. (eg. Little Jimmy watches too much TV because his dad watches too much TV). 5, 000 words... leave til last to write this section Research Aims Offering chaotic causality: Thousands of different influences which are in constant flux, the sum total of which manifest in action. 5 parts, each 8,000 words (publishable) total 40,000 words 10,000 words... Oct - Mid Nov Interview transcripts Epistemological consistency - using quant work. Having my cake and eating it? Heuristics 10,000 words - mid Nov - Jan Short summary of aims and questions Key Literature 5 - 10,000 words Discussion Empirical Findings How is the choice of methods and interpretation of data affected by particular questions and the nature of scientific objects? Present creative non-fiction at the start of each chapter which illuminates my point Producing data Knowledge (about health) and power (as a mediator) Language as a structured structuring structure Discourse and public knowledge - what we can and can't say, and what we can and can't think Methodology A Sociology of Physical Activity Promotion for Young People Methodological Approach Implications Visual Methods: Burke Sarah Pink Gillian Rose D. Macdougall What is important is not whether person X is a boy or a girl, but rather how that person perceives gender, how they relate to gender and how important gender is to their involvement with PA. Begin with summary Ethnography: Philosophy of science: Kuhn, T. The structure of scientific revolutions, 501/KUH Baskar, R. A realist theory of science... Reclaiming Reality Smith, John. The Logic of Justification Peters and Hurst Kant, Critique of Pure Reason Popper Hempel Hume Feyerabend The questions are about meaning, subjectivity, and influence of the social world. The objects are interpreted and socially constructed. Therefore it is better not to assume that (a) the structure has been interpreted the same by everyone, and (b) the structure has the same causal power Reflexivity Multiple Analysis (IPA, FDA) Coding process

PhD thesis

Transcript: PhD thesis Effect of Quercetin on some molecular implantation factors (integrin avb3, IGF1R) expression, COX 2 activity and apoptosis in STZ-induced diabetic mice Investigation of molecular mechanisms of diabetic embryopathy question Investigation of ameliorative effects of quercetin supplementation prior to conception/pregnacy on the diabetic embryopathy Objectives question investigation of ameliorative effects of quercetin on the preimplantation embryo development, blastocyst quality/implantationa and ovarian fullicologenesis in STZ- induced diabetic female mice. Condidate hub pathways and genes involved in the deleteriuos effects of diabetes on the preimplantation embryo development and blastocyst implantation Investigation of ovarian fullicologenesis in diabetic mice modelas procedure & materials 05 04 03 Procedures 02 01 Searching in GEO and Array Express to find datasets Implantation sites counting in the uterus Follicular classification Implantation sites Hormones levels So what? Quercetin administration at high doses augmented serum estrogen levels in early pregnancy. Quercetin has also been found to stimulate both types of estrogen receptor alpha (ERα) and beta (ERβ). Quercetin has also been shown to cause morphological and proliferative changes in uterus tissue. Quercetin stimulates cell proliferation through its effect on estrogen receptors, but the main mechanism is yet to be elucidated. Quercetin can affect estrogen synthesis in the ovary as indicated that quercetin increase the aromatase activity in granulosa cells. Gene expression uterus Expression of igf1r, integrin av, integrin b3 and cox2 genes in the uterus tissue So what? Expression of igf1, Integrin avb3 and cox2 which increases during embryo implantation, is dependent on estrogene. Dysregulation of IGF1-related genes can result in adverse pregnancy outcome. Igf1 is a paracrine mediator of stromal-epithelial cross-talk involved in epithelial proliferation during pre-implantation period, resulting in embryo implantation. Integrin αvβ3 found to involved in trophectoderm adhesion, and its absence was reported to interfere with embryo attachment. so what? cox2 gene expression during the adhesion phase is critical for implantation. Reduced cox2 expression in the uterus of diabetic mice at the implantation time cause failure in implantation. We propose that quercetin may able to ameliorated expression of igf1r, Integrin αvβ3 and cox2 genes by improving the ratio of estrogen/progesterone. Embryo development Assessment of embryo development Number and developmental stage of flushed embryos per mice So what? Diabetic pregnancy is associated with impaired development of the preimplantation Embryo. Blastocysts collected on day 5 of pregnancy contain fewer cells in the ICM in diabetic pregnant rat. Embryos retrieved from diabetic mice presented significantly delayed morphological development, as shown by a lower proportion of expanded blastocysts. Retarded embryos were either morulae or early blastocysts with a corresponding normal morphology or degenerated structures in diabetic mice. When diabetic mice were treated with 30 mg/kg/day quercetin, the morphological distribution also was significantly shifted to the well-developed stages. Gene expression blastocyst Expression of igf1r, integrin av, b3, cox2 genes So what? Insulin-like growth factor 1 is one of the important factors playing a role in the development of the embryo and its production by oviduct stimulate by estrogen. IGF1 receptors (IGF1R) has been identified on the mice preimplantation embryos. Several studies have revealed a crosstalk between estrogen and IGF signaling pathway. We propose that quercetin could increase igf1r mRNA expression in the blastocyst of diabetic mice by its estrogenic effects. As previous studies have demonstrated, hyperglycemia leads to the destruction of the prostaglandin synthesis in the preimplantation embryo. We indicated that diabetes can interfere with the production of PGs by reducing expression of cox2 mRNA, as a limiting enzyme in the PGs synthesis pathway. Previous studies also have indicated that diabetes adversely affects the expression of some integrin genes in different organs and cells. According to our results, quercetin administration in diabetic mice has ability to recover of integrin αvβ3 and COX2 genes expression to the normal levels in blastocysts of diabetic mice by antihyperglycemic and estrogenic effects. Our hypothesis We suggest that the low physiological level of estrogen may compromise embryo development and blastocyst quality in these diabetic mice and quercetin could alleviate the deleterious effects of diabetes on the embryo by increasing the serum estrogen levels in diabetic mice. Phospho-beta-catenin protein level Ser33/37/Thr41phospho-beta-catenin protein level in the uterus tissue Ser33/37/Thr41phospho-beta-catenin protein level in the blastocyst So what? The canonical Wnt/beta-catenin signaling pathway contributes to the cell

Thesis PhD presentation

Transcript: b Y 2 X g m 1 p A Pharmaceutical study on an analgesic drug under supersvision of : Kaadadf F E Add more content here Next Topic Add More Slides Present all the details Life is an Open Book.. D Ready to Turn the Next Page? C A Perfect Template for Various Topics: A Perfect Template for Various Topics: B "There is no friend as loyal as a book." - Ernest Hemingway "So many books, so little time." - Frank Zappa "Don't read books. Make prezis!" - Author Thank you! A

PhD Thesis Presentation

Transcript: IL-5 TGF-B T-regs Amostras de sangue + -Dra. Silke Paust -Dra. Laura D'Angelo -Dra. Mayra Sanabria-Hernandez -Duy Lee -Satya Bellamkonda Produção Sujeitos -Investigar a produção de adenosina pelas células tumorais de ovário e mecanismos de inibição das células NK através do receptor de adenosina A2A nas células NK. Expressão de ectonucleotidases CD39 e CD73 Células T-reg Modulação da resposta imune TGF-B Isolação do sobrenadante Artigo 1 -Dr. Fernando Guimaraes -Dra. Sophie Derchain -Dra. Adriana Yoshida -Dr. Rodrigo Jales -Dra. Daniela Cardozo -Carol Natania -Coletadas por paracentese guiada por ultrasonografia. -Isolamento da fração solúvel. -Isolamento da fração celular. Artigo de revisão TGF-B Referências 1. Siegel RL, Miller KD, Jemal A (2017) Cancer Statistics. CA Cancer J Clin 67:7-30. 2. da Silva RF, Petta CA, Derchain SF, Alici E, Guimarães F (2014) Up-regulation of DNAM-1 and NKp30, associated with improvement of NK cells activation after longterm culture of mononuclear cells from patients with ovarian neoplasia. Hum Immunol 75:777–784. 3. Lotzova E, Savary CA, Freedman RS, Edwards CL, Wharton JT (1988) Recombinant IL-2-activated NK cells mediate LAK activity against ovarian cancer. Int J Cancer 42:225–231. 4. Carlsten M, Björkström NK, Norell H, Bryceson Y, van Hall T, Baumann BC, Hanson M, Schedvins K, Kiessling R, Ljunggren HG, Malmberg KJ (2007) DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res 67:1317–1325. 5. Trzonkowski P, Smit E, Mysliwska J, Dobyszuk A, Mysliwski A (2004) CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-to-cell interaction. Clin Immunol 112:258-67. 6. Ghiringhelli F, Ménard C, Terme M, Flament C, Taieb J, Chaput N, Puig PE, Novault S, Escudier B, Vivier E (2005) CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-B-dependent manner. J Exp Med 202:1075– 1085. 7. Carlsten M, Norell H, Bryceson YT, Poschke I, Schedvins K, Ljunggren HG, Kiessling R, Malmberg KJ (2009) Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells. J Immunol 183:4921–4930. 8. Pesce S, Tabellini G, Cantoni C, Patrizi O, Coltrini D, Rampinelli F, Matta J, Vivier E, Moretta A, Parolini S, Marcenaro E (2015) B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape. Oncoimmunology 4(4):e1001224. 9. Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R, Gould D, Ayhan A, Balkwill F (2007) The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. Cancer Res 67:585–592. 10. Landskron J, Helland O, Torgersen KM, Aandahl EM, Gjertsen BT, Bjorge L, Tasken K (2015) Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. Cancer Immunol Immunother 64:337–347. 11. Young A, Mittal D, Stagg J, Smith MJ (2014) Targeting cancer-derived adenosine: New therapeutic approaches. Cancer Discovery 4:879-888. 12. Häusler SFM, del Barrio IM, Strohschein J, Anoop Chandran P, Engel JB, Hönig A, Ossadnik M, Horn E, Fischer B, Krockenberger M, Heuer S, Seida AA, Junker M, Kneitz H, Kloor D, Klotz KN, Dietl J, Wischhusen J (2011) Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity. Cancer Immunol Immunother 60:1405-1418. Amostras de ascite Heparina % CD107a nas células NK -Cromossomos afetados pela CNVs incluiu 10.523 genes. 8.798 genes com CNVs em ambas as células primárias malígnas e CAISMOV24, 710 somente na CAISMOV24 e 1.015 somente nas células primárias malígnas. -Serosos de baixo grau tem mutação nos genes KRAS e BRAF e são exclusivas. Ao contrário do de alto grau, ao qual a mutação está no TP53 e raramente no KRAS (Fernandéz et al 2016 e McIntyree et 2017). -CAISMOV24 contém mutação no gene KRAS e é wild type para TP53, caracterizando-a em uma linhagem de carcinoma seroso de baixo grau de ovário. Agradecimentos Avg=58 Condições fisiológicas -Linhagens de carcinoma seroso de baixo grau de ovário são limitadas na literatura. -Células malígnas de ovário podem ser cultivadas in vitro por um período limitado, somente uma minoria se tornam linhagens. -A imortalização espontânea não ocorre com frequência. O´Donnell et al. 2014, relatou a imortalização de 1 amostra entre 156. -A imortalização é frequentemente atribuída à instabilidade genética das células malígnas e acumulação de alterações genômicas, como o ganho e perda de sequências genômicas. -Essas alterações podem afetar as linhagens celulares, afastando-as do perfil inicial do tumor, ao qual limita sua utilidade em modelos experimentais. Imunomodulação por adenosina Citocinas Imunossupressoras Tratamento de tumores de estádio avançado Coleta

PhD Thesis

Transcript: Elliot Tebbe, PhD Debra Hope, PhD Neeta Kantamneni, PhD Thesis Proposal Alexander L. Farquhar-Leicester The Intersection of Transgender and Gender-Diverse Identity and Neurodiversity: An Exploratory Study and Application of Minority Stress Theory Doctoral Student, Counseling Psychology Problem Statement 01 Voices “Disability is articulated as a struggle, an unnecessary burden that one must overcome. But disabled lives are multifaceted…brimming with life. Though invisible, we are here” (22, queer, genderqueer, learning disability) “My disability exists not because of my bodymind, but because the broader environment isn’t accessible.” (19, gay, transgender, learning disability) "I am non-binary. I also have ADHD and autism. Both matter. I am capable of success, but my capacity and facility to achieve within academic institutions is always questioned by those around me. That’s my biggest hurdle...not my identities” (20, queer, non-binary, ADHD and autism) TGD and neurodivergent individuals are treated as homogeneous populations Little attention paid to the ways in which one marginalized identity may intersect with other forms of privilege and/or oppression to shape individuals' experiences on college/university campuses No research that examines the intersection of both identities and the ways in which multiple systems of oppression may affect these individuals’ health and functioning and academic success Problem Statement Literature Review 02 Recent trend toward intersectional research that is interested in and concerned with the ways individuals with multiple marginalized identities disproportionately experience higher rates of negative mental and physical outcomes as a result of intersecting stigma, marginalization, etc. (Cole, 2009; Moradi & Grzanka, 2017): gender (sexism, cisgenderism) race/ethnicity (racism, xenophobia) sexual orientation (heterosexism) socioeconomic status (classism) Multiple & Intersectional Forms of Oppression there are unique, additive, and interactive effects between multiple forms of oppression and psychological distress (Grollman, 2012; Szymanski & Meyer, 2008; Szymanski & Sung, 2010; Velez, Moradi, & DeBlaere, 2015) health outcomes vary across social identities and subgroups within trans populations (Budge, Thai, Tebbe, & Howard, 2016) Multiple & Intersectional Forms of Oppression discrimination, harrassment, lack of visibility/representation, and marginalization are quotidian experiences within institutions of higher education (Bilodeau, 2007; Finger, 2010; Rankin et al., 2013; Sleeman, 2013) lower perceptions of saftey, higher rates of violence, self-injury, suicidal ideation and suicide attempts, and negative health symptoms (Effrig et al., 2011; Messman & Leslie, 2018) more likely to consider dropping out of their college/university (Messman & Leslie, 2018) TGD Students higher levels of emotional and psychological distress, lower quality of life (Smedema et al., 2015) higher perceived and/or expereinced stigma within and outside of educational settings (Humphrey & Lewis, 2008) diability bias and stigma within institutions of higher education, including from instructors, advisors, and fellow peers (Baker, Boland, & Nowik, 2012; Doowrick, Anderson, Heyer, & Acosta, 2005; Yessel, Pak, & Beilke, 2016) higher risk for poor academic performance and early departure from college (Blasé et al., 2009; Kent et al., 2011; Smedema et al., 2015) Neurodivergent Students narratives of sexual and gender-diverse individuals with intellectual disabilities (IDs) correlation between autism symptomology and gender dysphoria (GD) traits TGD Identity and Autism Spectrum Disorder much of the research on TGD populations has centered on experience based on gender identity and expression, neglecting how experience might also be shaped by other intersecting axes of priveledge and/or marginalization based on other social identities a dearth of research that considers the intersectional effects and lived experience of TGD people with neurodivergent identities neurodivergence is often treated as a "mental illness", a problem within the individual downplays social realm Limitations Present Study 03 focus on the experiences and mental health and academic success of neurodivergent TGD undergraduate students who may experience marginalization along multiple dimensions investigate how distal (i.e., discrimination, rejection, harassment) and proximal (i.e., self-stigma, stigma consciousness) stressors impact these students Research Aims Intersectionality imperative to consider and explicate the unique experiences associated with marginalization and privilege on the basis of multiple markers of social categories/identities need to examine oppression among multiple axis of social positioning Minority Stress individuals with non-dominant identities experience stress above and beyond that of general daily stress this stress contributes to and exacerbates negative psychological health and functioning Research Frameworks

PhD thesis

Transcript: Reduced mortality among adults with a smallpox vaccination scar in Guinea-Bissau Reduced susceptibility to chronic diseases in high income countries Reports of "positive side-effects" on infections Studies of lower Crohn's disease, diabetes, multiple sclerosis and asthma Lower risk of cancers Longer survival of melanoma patients Hypothesis Children in CSHRR born 1965-1976 Background cohort n=47.622 Eligible cohort n=46.239 Possible Non-targeted Protection against Infections and Inflammatory Diseases by Smallpox Vaccination Outline of the presentation Smallpox vaccination in Denmark Photo: History of vaccine.org This research has been co-financed by the European Union (European Social Fund – ESF) and Greek national funds through the Operational Program "Education and Lifelong Learning" of the National Strategic Reference Framework (NSRF) - Research Funding Program: Heracleitus II. Investing in knowledge society through the European Social Fund. Studies in the thesis Information entered for the vaccination project: Family factors Health factors Vaccinations Danish Study Population Smallpox vaccination protects against non-targeted infections and inflammatory diseases Photo: FynskeBilleder.dk BCG reduce overall mortality Marie Villumsen Effects of a vaccine on morbidity and/or mortality that cannot be explained by the protection of the vaccine-targeted disease. Vaccination scar survey 2005-07 Hypothesis Results Perspectives 496 cases of IBD was identified No difference in smallpox vaccination status between cases and individuals in the subcohort HR=1.01 (95% CI: 0.77-1.32) No effect was seen when analysing Ulcerative colitis or Crohn's diseases separately. No sex differential effects Paper IV Risk of lymphoma and leukaemia after bacille Calmette-Guerin and smallpox vaccination: a Danish case-cohort study Paper V Risk of Inflammatory Bowel Disease following Bacille Calmette-Guerin and Smallpox Vaccination: A Population-based Danish Case-Cohort Study Vaccinated before age 3.5 years may be most protective Variola virus The studies add to the evidence of non-targeted protection against infections by smallpox vaccination No interaction between smallpox vaccination and year of birth Studies of smallpox vaccination and infections should be repeated in other populations PhD defence 10 April 2014 Compulsory by law 1810 DTP increase overall mortality in girls The narrow time window of phase out of smallpox vaccination and the size of the study population limit the conclusion of effects of smallpox vaccination and inflammatory diseases Study area of Bandim Health Project Evidence of non-specifics effects of vaccination Available information: Name, year of birth (CPR number) and sex HIV survey 2004-06 Paper II Smallpox vaccination scar and Prevalence of HIV-1 in Guinea-Bissau Paper III Smallpox vaccination and incidence of HIV hospital admissions: A Danish register-based case-cohort study Sampling of study population PhD defence 10 January 2014 Smallpox vaccination Copenhagen Municipal Archives of School Health Records Measles vaccine reduce overall mortality Cow pox Smallpox Smallpox vaccination scar reduce prevalence of HIV-1 in women in Guinea-Bissau (OR=0.45, 95% CI 0.22-0.91) Smallpox vaccination reduce incidence of HIV-1 in women without IDU in Denmark (HR=0.29; 95% CI 0.09-0.93) No effect of smallpox vaccination in males Paper I Smallpox vaccination and all-cause infectious disease hospitalization: a Danish register-based cohort study Marie Villumsen No difference in smallpox vaccination status was seen in cases of leukaemia, lymphoma or inflammatory bowel disease. However, the number of cancer cases included in the analyses were small. Study population Variolation First vaccine 1801 Paper III, IV and V Paper I Pilot study of vaccinia antibodies Objectives African Study Population Photo: CDC James Gathany Measles vaccine reduce overall childhood mortality DTP increase mortality in girls BCG reduce overall mortality in neonates and children Sex differential effects of vaccines History of smallpox vaccination Copenhagen School Health Record Register a unique source for studies of smallpox vaccination Discussion Copenhagen School Health Record Register Aaby et al. BMJ 2010 Non-specific effects of vaccines Possible Non-targeted Protection against Infections and Inflammatory Diseases by Smallpox Vaccination Phased out in the 1970s Introduction Background Methods Results paper I: Infectious disease hospitalisation Results paper IV and V: Inflammatory diseases Results Paper II and III: HIV Pilot study: Vaccinia antibodies Discussion and perspectives Methods To investigate non-specific effects of smallpox vaccination on infections and inflammatory diseases Paper I Smallpox vaccination and all-cause infectious disease hospitalization: a Danish register-based cohort study (Int J Epidemiol 2011) Paper II Smallpox vaccination scar and Prevalence of HIV-1 in Guinea-Bissau (Manuscript submitted 2013) Paper III Smallpox

PhD Thesis Presentation

Transcript: Alastair van Heerden Pervasive computing and public health research in Africa: Mobile phones in the collection, analysis and dissemination of health research

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