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Transcript: Vogue Roll up to Marisa Bartolucci's Magical Mystery Career Tour I learned the craft of magazine writing, editing, and styling at Vogue. Anna Wintour, then creative director, was a mentor. Issy Blow and André Leon Talley were my office mates. André was slim back then!

Gears Presentation

Transcript: Worm and wheel The Simple Gear Train with Idler is basically EXACTLY like the Simple Gear Train except instead of two gears there are three. The third gear is called an idler. There ya go! It's like the two gears are a couple and the idler is the third wheel! *class looks at me with death stare* Hey I'm trying to make this fun okay?! I'm bored out of my mind too! *storms off to next slide again* The Simple Gear Train is simple. Well, how it works is pretty simple. All you have to do is turn the crank to make the gears move and there you go. You have yourself a gear train. Where do you find it? Well the gear train is used where there's a large distance to be covered between the input shaft and the output shaft. Yeah, you see me using vocab. Skillz. By - NeVaeh Washington Simple Gear Train Okay so the Worm and Wheel is another level of difficulty. I guess you could say that it's on the easy-but-not-SO-easy level. Simple Gear Train with Idler Gears Presentation What is this Presentation about? Okay *sighhhhhhhhh* this presentation is basically just me telling you about the builds we made in Mr. Coach Register's class. In this prezi, I chose to talk about the Simple Gear Train, Simple Gear Train with Idler, the Worm and Wheel, the Leadscrew, the Crank and Slider, the Bevel Gear, and finally, the Belt Drive. *hears long, exaggerated sigh from crowd*. Hey! I don't want to do this either but it's a grade so be quiet and let me talk, hmph! *storms off to next slide* add logo here

Gears Presentation

Transcript: Belt Drive The gear train with idler is usually made up of two or more gear. The A and B gear speed the same and the C is the Idler it speed the different way. Worm and Wheel The gear train is a mechanical system formed by mounting gear on a frame so that the teeth of the gear engage. Gear Train A lead screw pitch and diameter are a perfect combination high torque and speed. Bevel Gear Chain Drive Gear Train with Idler A worm drive is a gear arrangement in which a worm in the form of a screw meshes with a worm gear which is similar in appearance to a super gear. Gears Presentation The universal joint offers good beer and great food with friendly neighborhood atmosphere and an easygoing bar scene Lead screw Crank and Slider A cam and follower also know as a track follower is a specialized type of roller or needle bearing designed to follow cam lobe profiles Belt Drive are two types they are open belt drive and crossed belt drive there are advantages disadvantages of having belt drive The bevel gear are useful when the direction of a shaft's rotation needs to changed. The teeth on bevel gear can be Straight, Spiral or Hypoid A mechanism in which power is transmitted from an engine, typically to the wheels of vehicle or a boat's propeller, by mean of moving endless chain A crank and slider mechanism changes rotary to reciprocating motion or vice into rotary motion as the con-rod moves the crankshaft around. Cam and Follower Universal Joint

Gears! Gears! Gears!

Transcript: Team Captain: Hannah Preaus Critical Thinking The Process After following the instructions, we built our first robot! Collaboration within our team Engineer: Lindsie Bostrom Our Team! Robotics in the Classroom Back to the drawing board! The Pre-K Programmers Our team finally accomplished building a robot that functioned for competition. The goal was to get to the finish line the fastest. After lots of team work, problem solving, creative and critical thinking, and gaining an understanding of how robotics and the gears work, we were able to finish and win the final competition! "What could we change?" Hannah made a comment that summed up the feelings of the whole group when she said, "After I left class this week and got in my car, I thought building the robot was complicated. I can't imagine what went into building my car!" Reporter: Lacy Wycoff Artisan: Virginia Dobbins When it was possible, the team captain, engineer, and artisan divided duties and built pieces separately and combined them to check compatibility. "If the gears aren't moving, the robot isn't moving!" After deciding which team member would play each role, we decided on a gears kit named Giggles. We found all of the pieces needed to build our robot and followed all of the instructions in the booklet. After the modifications failed, we decided to start from scratch with a different model named Chompers. We picked Chompers because we could tell that this robot could move forward and backward and would serve us better in the competition. During the build, our team asked questions and helped one another through the process. At one point while building our second robot, Hannah asked Lindsie, "Can you help me get back to step 1? I feel like we missed an entire step." Adaptations to Robot No. 2 We added a set of wheels hoping for forward motion The Pre-K Programmers The Gears! Gears! Gears! Wacky Wigglers Building Set is a gears robotic system created to develop creativity and imagination in children ages 5 and up. The kit comes with instructions and parts to build four silly creatures that operate off batteries and a remote control. Unfortunately, we discovered some issues with our first robot so we sat down to do some problem solving. We were building a robot that would need to be able to compete in a challenge against another robot. Once all of our pieces were together, we discovered that our robot danced in circles and would not be able to cross a finish line. We needed to modify the robot to make it roll forward and to gain speed. Final Thoughts of the Team Gears! Gears! Gears! Robot No. 1 We couldn't believe the thought and detail that went into building an early childhood/elementary level robot. We learned that following step by step instructions isn't enough. Working together, being creative, and willing to make changes is what lead to our success as a team. Chompers before modifications Chompers was top heavy! We had to get creative and remove Chomper's chompers in order to keep it upright. The Competition! The Product Jobs Making some modifications Collaborating with the opponents Chompers after modifications

Gears Presentation

Transcript: Transmissions and Bikes Machines and Vacuums Toys and Clocks Etc. Uses Mechanical Advantage Not really a worm Worm Gears EX: 8 driving 40, Ma = 5 Gear Trains Toothed Gears Driven Divided by Driver Multiply MA if Gear Train Gears

HD Presentation

Transcript: 1860 http://www.uihealthcare.com/topics/medicaldepartments/neurology/huntingtonsdisease/overview.html Charles Davenport Dementia that gets worse Disorientation Loss of judgement Loss of memory Personality changes Speech changes Additional symptoms Anxiety, stress, tension Symptoms in children Rigidity Slow movements Tremors So what do you think this repeat would do to gene function? 1911 Transcriptional dysregulation Protein misfolding and degradation Impairment in intracellular transport, mitochondrial function and synaptic transmission. http://www.stanford.edu/group/hopes/cgi-bin/wordpress/2010/06/the-cognitive-symptoms-of-huntingtons-disease/ Post translational modification-acetyl tag signal SirT1 inhibition, Selisistat Phosphodiesterases inhibitors: PDE 10 and 4 now in testing Gene silencing Stem cell generation of neurons Bruproprion Manipulation of synaptic activity - Memantine Ch Implications of HD http://atlasfolding.com/?page_id=51 Current Therapies https:///nm/journal/v10/n7s/full/,DanaInfo=www.nature.com+nm1066.html Genetic Testing Why Test Mid Stage 1872 Works Cited Amber Johnson, Hannah Killian, Sarah Tamura https://www.stanford.edu/group/hopes/cgi-bin/wordpress/2010/06/the-inheritance-of-huntingtons-disease-text-and-audio/ Basic Symptoms http://schoolworkhelper.net/huntingtons-disease-causes-symptoms-testing/ Mood changes Movement changes Cognition changes Two Forms Huntington's Disease Alzheimer's disease Parkinson's disease Amyotrophic lateral sclerosis (ALS) Prion diseases (CJD kuru etc.) Lose ability to speak and respond Chorea Lose ability to work, drive, perform activities of daily living Difficulties with balance and motor tasks Difficulties with processing information Irritability, aggression, depression Can be done safely More serious than a simple blood test Challenging psychological and social aspects Genetic Information Non-discrimination Act (May 21st 2008) Medical Value? Testing of Minors Anonymous Testing Testing of individuals at 25% risk 1846 Over 80 testing centers nation wide Emotional and ethical issues that come with HD diagnosis - no treatment to delay onset of HD symptoms, cannot cure HD Psychological support is very important ~ 10-20% of people at risk for HD request testing Grade 0: appears indistinguishable from normal brains after gross examination. Grade 1: shows atrophy in the tail, and in some cases the body, of the caudate nucleus. Grade 2: is associated with striatal atrophy that is more pronounced than that detected in grade 1 brains. Grade 3 displays severe striatal atrophy. Grade 4 includes HD cases with severe atrophy of the striatum and up to 95% neuronal Confirmatory/Diagnostic Testing Predictive Testing Prenatal Testing Grading Based on pattern of Striatal Degeneration Stages 1-2 http://www.nature.com/nrn/journal/v5/n5/fig_tab/nrn1386_F1.html Huntington's vs. Neurodegenerative Diseases Adult-onset : most common ages 30 to 50 Early-onset: small number of cases Worsen in 10-25 year period 1 in every 10,000 Americans has HD and more than 250,000 are at risk Most common hereditary disease Behavior Behavioral disturbances Hallucinations Irritability Moodiness Restlessness or fidgeting Paranoia Psychosis Abnormal movements Facial movements Head turning Jerking movements of arms, legs, face etc Slow uncontrolled movements http://www.cumc.columbia.edu/psjournal/sites/juno.cumc.columbia.edu.psjournal/files/Huntington.jpg Johan Christian Lund Dr. Huntington Late Stage Ambrose, C. M.; Duyao, M. P.; Barnes, G.; Bates, G. P.; Lin, C. S.; Srinidhi, J.; Baxendale, S.; Hummerich, H.; Lehrach, H.; Altherr, M.; Wasmuth, J.; Buckler, A.; Church, D.; Housman, D.; Berks, M.; Micklem, G.; Durbin, R.; Dodge, A.; Read, A.; Gusella, J.; MacDonald, M. E. "Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat". Somatic Cell & Molecular Genetics; 1994, 20: 27-38. Conforti, P., Camnasio, S., Mutti, C., Valenza, M., Thompson, M., Fossale, E., . . . Cattaneo, E. (2013). Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death. Neurobiology of Disease, 50, 160-170. doi: 10.1016/j.nbd.2012.10.015 Giampà, C., Laurenti, D., Anzilotti, S., Bernardi, G., Menniti, F. S., & Fusco, F. R. (2010). Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of huntington's disease. PloS One, 5(10), e13417. Gil, J. M., & Rego, A. C. (2008). Mechanisms of neurodegeneration in Huntington’s disease. European Journal of Neuroscience, 27(11), 2803-2820. Graul, A. I., & Prous, J. R. (2005). Executive summary: nicotine addiction. Drugs of Today, 41(6), 419. Ho, L. W.; Carmichael, J; Swartz J; Wyttenbach A; Rankin J; Rubinsztein DC. "The molecular biology of Huntington's disease." Psychologocial Medicine; 2001, 31(1): 3-14. Huntington’s Outreach Project for

HD Presentation

Transcript: High Definition -It has a higher resolution than traditional tv's. -the top of the digital television. -High Definition TV/CPU can display images and videos with a higher quality than those found in a standard television. -The difference between SD and HD is that its better quality. But thats only if your computer or Tv/CPU can handle it. -HD you get much more of the experience out of the movie. -Sd is the still the most prominent format for televisions and standard computers. This means that the TV/ Computer you are buying is ready to display at a High definition signal right out of the box. Pixils An Example: HD CPU 30 -Standard definition - It is also cheaper than a HD TV or Computer. - The pixils for SD is lower than its comparision. S.D. ? What is HD? Whats Different about HD than Standard ? SD Wowing template. Click through in 20 steps. High Def Televisons Videos Here is something small... But we can move beyond the present. Why?

Gears presentation

Transcript: Gear trains First a drive shaft will be put through one side which will then have a cam attached to it. Then a bar will be attached to the cam at the bottom which will then connect to slide truck on a linear slide and when the cam is turned by a crank the slide truck will move along the linear slide. Are also used in cars. Belt drive Bevel gears One of the gears will have a crank attached to it that when turnt will ause the gear to turn which will then cause the other attached gear to turn the opposite way. Can also be used in cars. By:Jordan Runnels Leadscrew First a drive shaft will be put through two mounting brackets, then a slide truck will be attached to a linear slide by screws. Then finally 4 worm gears will be attached and slid through the anvil looking thing in the middle and when the crank is turned the screws will cause the anl to move along depending on which way the screws are turning. Crank slider Chain drive Small to big gears one long and one short spindle looking gears will be placed apart from each other and then connected by a rubber band and when one of the gears is turned the rubber band will cause the oter gear to turn also. Are used in cars. There are two gears that are put a good distance away from each other and then are attached by a chain. when one of the gears is turned the chain will cause the other gear to also turn the same way. Can be found in cars. Gears presentation Gear reduction There will be two gears attached together verticaly to form a corner and when one of the gears is turned it will cause the other to turn the other way. Are used in hand drills. Big to small gears When a chain drive goes from small to big gears though the speed will be increased and the torque will be increased. Cam and follower first a cam will be attached by a drive shaft bellow a cam follower and bracket which will hold the follower. And a crank will be attached to the cam and when it is turned the cam follower will go up and then down. Used in cars. When a chain drive goes from big to small gears speed will be decreased but the torque in the chain will be increased.

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