RAFT Cover Sheet
Transcript: This red blood cell has Regular Hemoglobin Audience Parents can either be carriers of the trait and not have the disease with one irregular hemoglobin gene, or actually have the disease with two irregular hemoglobin genes. Several punnett squares below outline who can and cannot inherit SCD. Certain medications like Hydroxyurea can greatly Who is more likely to have SCD? of pain & acute chest Carrying SCD Irregular Hemoglobin molecules within this red blood cell change its shape considerably! reduce the frequency However, SCD is quite elusive before the victim is 6 months of age syndrome episodes Irregular Hemoglobin? How? Result: 1:1 No SCD:Carrier ratio There aren't many side effects to SCD treatments. RAFT Cover Sheet SCD is symptomatically treated. No true cure exists. Works Cited Format SCD is Painful. How is it treated? 0.2% of African Americans are born with SCD 0.0027% of Hispanics are born with SCD Anemia Early strokes Infection susceptibility Spleen problems Acute-chest syndrome What kind of genetic disorder is causing this? Sickle-shaped red blood cells are sticky and oblong, which causes them to clot easily. Today we will be learning about a very serious genetic disorder, called "Sickle Cell Disease" (SCD) Result: 1:2:1 No SCD:Carrier:SCD ratio Carrier x carrier Sickle Cell Disease overview Welcome, Class! Generally, acute and variable-length pains are resultant from clots Many types of pain exist, and they can start almost anywhere in the body Particularly identifiable pains include dactylitis, which causes swelled digits Detectability of SCD is quite high due to the high-intensity pain involved Thank you for your time Often, blood transfusions are utilized to increase the number of regular red blood cells in the body. This helps with pain episodes and anemic issues & strokes Antibiotics help with infection "Complications and Treatments." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 17 Jan. 2014. Web. 05 Feb. 2015. <http://www.cdc.gov/ncbddd/sicklecell/treatments.html>. "Facts About Sickle Cell Disease." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 16 Jan. 2014. Web. 02 Feb. 2015. <http://www.cdc.gov/ncbddd/sicklecell/facts.html>. "Sickle Cell Trait." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 04 June 2013. Web. 06 Feb. 2015. <http://www.cdc.gov/ncbddd/sicklecell/traits.html>. "Sickle Cell Trait." Wikipedia. Wikimedia Foundation, n.d. Web. 2 Feb. 2015. <http://en.wikipedia.org/wiki/Sicklemia>. "Sickle-cell Disease." Wikipedia. Wikimedia Foundation, n.d. Web. 02 Feb. 2015. <http://en.wikipedia.org/wiki/Sickle-cell_disease>. While a child needs two genes to inherit the disease, they can still carry one gene However, this red blood cell is shaped like a Sickle! Sickle Cell Disease causes red blood cells to be deformed and sickle-shaped, which causes many problems SCD affects "90,000 to 100,000 Americans" (CDC) Genetic disorder and mutation cause the body to produce irregular hemoglobin molecules. These molecules are abnormal and cause the sickle-shaped cells to form. Non-carrier x carrier Regular antibiotic use can also reduce its effectiveness. The disease is located on Chromosome 11, which handles most of hemoglobin production People usually figure out they have SCD due to the many complications sickle-shaped red blood cells cause. Class of biology students SCD also causes issues like... Result: 1:1 SCD:Carrier ratio Not everyone gets tested... What are the symptoms? Topic Before this point, the body still utilizes fetal hemoglobin, which is never problematic. The victim may still have SCD, they simply do not show symptoms since they are not using their adult, inferior hemoglobin yet. These are all life-threatening issues! Other Problems Victim x carrier Role Purely based on statistics, SCD is "most common in people whose families come from Africa, South or Central America (especially Panama), Caribbean islands, Mediterranean countries (such as Turkey, Greece, and Italy), India, and Saudi Arabia" (National Heart, Lung, and Blood Institute). When blood clots... Matthew Silva Mrs. Christman However, Hydroxyurea is a cancer-drug and, as expected, has many flu-like side effects along with hair-loss. Any Side Effects? Prezi Many highly-visible symptoms occur when blood clots College student The mutated hemoglobin gene must be donated by each parent for the child to have SCD, in other words it is a recessive trait. See the Full, Circular form of this red blood cell?